Revealing a Continuity of Sequence Similarity Between Seemingly Unrelated Protein Structures

Sarah Page, Oberlin College

Location

Science Center, A154

Document Type

Presentation

Start Date

4-24-2015 4:00 PM

End Date

4-24-2015 5:30 PM

Abstract

Some protein domains share a common structure, but are dissimilar in amino acid sequence. It is not clear whether these proteins arose from an ancient common lineage or from two unrelated lineages that converged on a common structure. I use protein design software to create possible steps between these proteins, and find that some protein domains that traditionally have been classified as unrelated are connected by mutual sequence similarity to synthetic sequences. These results indicate a more fluid sequence space than previously thought.

Notes

Session 3, Panel 15 - Biology Honors
Moderator: Marta Laskowski, Professor of Biology

Major

Neuroscience

Advisor(s)

Tracie Paine, Neuroscience

Project Mentor(s)

Aaron Goldman, Biology

April 2015

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Apr 24th, 4:00 PM Apr 24th, 5:30 PM

Revealing a Continuity of Sequence Similarity Between Seemingly Unrelated Protein Structures

Science Center, A154

Some protein domains share a common structure, but are dissimilar in amino acid sequence. It is not clear whether these proteins arose from an ancient common lineage or from two unrelated lineages that converged on a common structure. I use protein design software to create possible steps between these proteins, and find that some protein domains that traditionally have been classified as unrelated are connected by mutual sequence similarity to synthetic sequences. These results indicate a more fluid sequence space than previously thought.