Suddenly, I Remember: Hormonal Treatments and Memory Rescue in an Animal Model of Schizophrenia

Alexander Riordan, Oberlin College

Location

Science Center, A255

Document Type

Presentation

Start Date

4-24-2015 4:00 PM

End Date

4-24-2015 5:30 PM

Abstract

Schizophrenia is a debilitating disorder, and current treatments fail to adequately reverse the condition’s most devastating symptoms, which include deficits in memory. In the present study, we show that inhibition of luteinizing hormone causes recovery of recognition memory in a rodent model of schizophrenia. We also replicate previous work showing that estrogen has a similar therapeutic effect. Finally, we present data suggesting that these treatments restore memory by repairing cells that act as “brakes” on brain activity—particularly in the hippocampus, a brain area important for memory.

Notes

Session 3, Panel 18 - Nature vs. Nurture Remixed: Studies in Regulation, Regeneration, Isolation, and Degradation
Moderator: Gunnar Kwakye, Assistant Professor of Neuroscience

Major

Mathematics

Advisor(s)

Jim Walsh, Mathematics

Project Mentor(s)

Jan Thornton, Neuroscience

April 2015

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Apr 24th, 4:00 PM Apr 24th, 5:30 PM

Suddenly, I Remember: Hormonal Treatments and Memory Rescue in an Animal Model of Schizophrenia

Science Center, A255

Schizophrenia is a debilitating disorder, and current treatments fail to adequately reverse the condition’s most devastating symptoms, which include deficits in memory. In the present study, we show that inhibition of luteinizing hormone causes recovery of recognition memory in a rodent model of schizophrenia. We also replicate previous work showing that estrogen has a similar therapeutic effect. Finally, we present data suggesting that these treatments restore memory by repairing cells that act as “brakes” on brain activity—particularly in the hippocampus, a brain area important for memory.