High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals
Abstract
Radicals with intrinsic stereogenic and radical centers offer a promising yet largely unexplored platform for synthetic chemistry. We reported a family of chiral sulfonimidoyl radicals that enable stereoretentive radical transfer by using our bench-stable reagents. This approach unlocked switchable, modular access to enantioenriched sulfoximines or sulfinamides, avoiding the use of strong oxidants and organometallic nucleophiles. Additionally, mechanistic studies and computational investigations provide insightful and plausible explanations for the observed high fidelity of these underexplored chiral sulfonimidoyl radical species.
Repository Citation
Li, Renzhe, Chang Liu, Wenyuan Li, et al. 2026. "High-Fidelity Transfer of Chiral Sulfonimidoyl Radicals." Journal of the American Chemical Society
Publisher
American Chemical Society
Publication Date
5-2026
Publication Title
Journal of the American Chemical Society
Department
Chemistry and Biochemistry
Document Type
Article
DOI
https://doi.org/10.1021/jacs.6c06952
Keywords
Sulfoximines, Resolution, Alkenes, Memory
Language
English
Format
text
