Formation of Amyloid Fibrils in Vitro by Human yd-crystallin and its Isolated Domains

Abstract

Amyloid fibrils are associated with a variety of human protein misfolding and protein deposition diseases. Previous studies have shown that bovine crystallins form amyloid fibers under denaturing conditions and amyloid fibers accumulate in the lens of mice carrying mutations in crystallin genes. Within differentiating lens fiber cells, crystallins may be exposed to low pH lysosome compartments. We have investigated whether human γD-crystallin forms amyloid fibrils in vitro, when exposed to low pH partially denaturing conditions.

Publisher

Molecular Vision

Publication Date

1-1-2008

Publication Title

Molecular Vision

Department

Chemistry and Biochemistry

Document Type

Article

Language

English

Format

text

Link to Full Text

Share

COinS