Analysis of BDNF production in the aging gerbil cochlea

Abstract

Degeneration of cochlear neurons is the most commonly observed cellular change in the aging human and gerbil cochlea. Although it is unclear what leads to this neuronal loss, changes in the production of target-derived trophic factors may be the ultimate cause of cochlear neuron degeneration. The present study used an enzyme-linked immunosorbent assay to investigate whether BDNF is produced by the organ of Corti or cochlear ganglia of young, middle aged, or aged gerbils. The results revealed an age-related increase in BDNF in the organ of Corti, but not in the cochlear ganglia.

Publisher

Elsevier

Publication Date

4-1-2000

Publication Title

Experimental Neurology

Department

Neuroscience

Document Type

Article

DOI

https://dx.doi.org/10.1006/exnr.2000.7353

Keywords

Inner ear, Organ of Corti, Spiral ganglia, Cochlear ganglia, Neurotrophin, Brain-derived neurotrophic factor, ELISA

Language

English

Format

text

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