Determination of trace level cadmium in SRM 3280 multivitamin/multielement tablets via isotope dilution inductively coupled plasma mass spectrometry

Abstract

Cadmium was quantified at 80.15±0.86 ng/g (mean±95% expanded uncertainty) in NIST SRM 3280 Multivitamin/Multielement Tablets, using isotope dilution mass spectrometry. The method described utilized various precipitation and solid-phase extraction separation methodologies to isolate Cd from Sn and Mo, present respectively, at 11.1±0.9 mg/kg and 70.7±4.5 mg/kg in the tablet matrix. This allowed for measurement of 111Cd/113Cd and 111Cd/114Cd isotope ratios using both quadrupole collision cell technology inductively coupled plasma mass spectrometry (Q-CCT-ICP-MS) and sector field (SF)-ICP-MS equipped with a desolvating nebulizer system to mitigate the MoO+ and MoOH+ molecular ion interferences that typically affect the envelope of Cd isotopes.

Publisher

Elsevier

Publication Date

1-1-2013

Publication Title

Talanta

Department

Chemistry and Biochemistry

Document Type

Article

DOI

10.1016/j.talanta.2013.04.068

Language

English

Format

text

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