Event Title
Exploring the Dual Role of Gas as a Tumor Suppressor and Oncogene
Location
Science Center, Bent Corridor
Start Date
10-27-2017 6:00 PM
End Date
10-27-2017 6:40 PM
Research Program
National Institutes of Health
Poster Number
33
Abstract
Basal cell carcinoma is the most common form of skin cancer, with more than 4 million people diagnosed each year (Wong, 2003). Formation of basal cell carcinoma could occur through deletion of Gαs or repression of Protein kinase A (PKA) signaling (Iglesias-Bartolome, 2015). Gαs, a heterotrimeric signaling protein, can act both as a tumor suppressor and an oncogene (Turan, Bastepe, 2015). The tumor suppressor function of Gαs seems to be mediated by activation of PKA, while the tumor promoting function of Gαs is potentially mediated by Exchange protein activated by cAMP (EPAC). We hypothesize that Gαs possesses both properties because it is mediated by different downstream signaling pathways.
Recommended Citation
Patel, Sonam, "Exploring the Dual Role of Gas as a Tumor Suppressor and Oncogene" (2017). Celebration of Undergraduate Research. 36.
https://digitalcommons.oberlin.edu/cour/2017/posters/36
Major
Anthropology
Project Mentor(s)
Ramiro Iglesias-Bartolome and Maria Del Pilar Pedro, National Cancer Institute
Document Type
Poster
Exploring the Dual Role of Gas as a Tumor Suppressor and Oncogene
Science Center, Bent Corridor
Basal cell carcinoma is the most common form of skin cancer, with more than 4 million people diagnosed each year (Wong, 2003). Formation of basal cell carcinoma could occur through deletion of Gαs or repression of Protein kinase A (PKA) signaling (Iglesias-Bartolome, 2015). Gαs, a heterotrimeric signaling protein, can act both as a tumor suppressor and an oncogene (Turan, Bastepe, 2015). The tumor suppressor function of Gαs seems to be mediated by activation of PKA, while the tumor promoting function of Gαs is potentially mediated by Exchange protein activated by cAMP (EPAC). We hypothesize that Gαs possesses both properties because it is mediated by different downstream signaling pathways.
