Event Title
The Role of the Extracellular Matrix in Modulating Muscle Progenitor Cell Behavior in an In VitroModel of Heterotopic Ossification
Location
Science Center, Bent Corridor
Start Date
10-28-2016 5:30 PM
End Date
10-28-2016 6:00 PM
Research Program
Uniformed Services University of the Health Sciences
Poster Number
39
Abstract
Heterotopic ossification (HO) is the existence of bone in soft muscle tissue where bone production should not usually occur. HO typically occurs following a traumatic wound injury: approximately 60% of wounded service members that suffer from limb loss or heavy tissue damage develop HO (Shehab, 2002). Such ectopic bone formation results in significant pain, inflammation, and reduced mobility (Shimono, 2013), underlining the need to discover the mechanisms through which HO may occur. One hypothesis is that the excessive scar tissue that results from these injuries promotes the dedifferentiation of resident muscle progenitor cells (MPCs). Once dedifferentiated, they may then redifferentiate into bone-producing cells. Here, we look specifically at how changes in the extracellular matrix affect MPC behavior and gene expression.
Recommended Citation
Patel, Sonam, "The Role of the Extracellular Matrix in Modulating Muscle Progenitor Cell Behavior in an In VitroModel of Heterotopic Ossification" (2016). Celebration of Undergraduate Research. 57.
https://digitalcommons.oberlin.edu/cour/2016/posters/57
Major
Anthropology
Project Mentor(s)
Youngmi Ji, Department of Surgery, and Leon Nesti, Clinical & Experimental Orthopedics Laboratory, Uniformed Services University of the Health Sciences
Document Type
Poster
The Role of the Extracellular Matrix in Modulating Muscle Progenitor Cell Behavior in an In VitroModel of Heterotopic Ossification
Science Center, Bent Corridor
Heterotopic ossification (HO) is the existence of bone in soft muscle tissue where bone production should not usually occur. HO typically occurs following a traumatic wound injury: approximately 60% of wounded service members that suffer from limb loss or heavy tissue damage develop HO (Shehab, 2002). Such ectopic bone formation results in significant pain, inflammation, and reduced mobility (Shimono, 2013), underlining the need to discover the mechanisms through which HO may occur. One hypothesis is that the excessive scar tissue that results from these injuries promotes the dedifferentiation of resident muscle progenitor cells (MPCs). Once dedifferentiated, they may then redifferentiate into bone-producing cells. Here, we look specifically at how changes in the extracellular matrix affect MPC behavior and gene expression.
