Event Title

High Precision Combustion Calorimetry of Co-Crystals

Presenter Information

Aaron Frederick, Oberlin College

Location

Science Center, Bent Corridor

Start Date

10-2-2015 12:00 PM

End Date

10-2-2015 1:20 PM

Poster Number

37

Abstract

Co-crystals are solids of interest to many chemists, particularly pharmaceutical and materials scientists. The experiments I performed this summer provide thermodynamic data on co-crystals containing active pharmaceutical ingredients (APIs) including caffeine, theophylline, nicotinamide, and piracetam. These APIs were ground with a series of di-acids to make cocrystals, then analyzed using combustion calorimetry. Using a Parr 6200 calorimeter, I calculated the enthalpies of combustion and formation of these co-crystals. This enthalpy data is the first step in quantifying the spontaneous formation of co-crystals in this series of APIs. Future steps include analysis using differential scanning calorimetry (DSC) to find the standard molar entropy of the co-crystals to solve for the Gibb’s free energy using the equation: ΔG = ΔH – TΔS.

Major

Chemistry

Project Mentor(s)

Manish Mehta, Chemistry and Biochemistry

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Oct 2nd, 12:00 PM Oct 2nd, 1:20 PM

High Precision Combustion Calorimetry of Co-Crystals

Science Center, Bent Corridor

Co-crystals are solids of interest to many chemists, particularly pharmaceutical and materials scientists. The experiments I performed this summer provide thermodynamic data on co-crystals containing active pharmaceutical ingredients (APIs) including caffeine, theophylline, nicotinamide, and piracetam. These APIs were ground with a series of di-acids to make cocrystals, then analyzed using combustion calorimetry. Using a Parr 6200 calorimeter, I calculated the enthalpies of combustion and formation of these co-crystals. This enthalpy data is the first step in quantifying the spontaneous formation of co-crystals in this series of APIs. Future steps include analysis using differential scanning calorimetry (DSC) to find the standard molar entropy of the co-crystals to solve for the Gibb’s free energy using the equation: ΔG = ΔH – TΔS.