Event Title
High Precision Combustion Calorimetry of Co-Crystals
Location
Science Center, Bent Corridor
Start Date
10-2-2015 12:00 PM
End Date
10-2-2015 1:20 PM
Poster Number
37
Abstract
Co-crystals are solids of interest to many chemists, particularly pharmaceutical and materials scientists. The experiments I performed this summer provide thermodynamic data on co-crystals containing active pharmaceutical ingredients (APIs) including caffeine, theophylline, nicotinamide, and piracetam. These APIs were ground with a series of di-acids to make cocrystals, then analyzed using combustion calorimetry. Using a Parr 6200 calorimeter, I calculated the enthalpies of combustion and formation of these co-crystals. This enthalpy data is the first step in quantifying the spontaneous formation of co-crystals in this series of APIs. Future steps include analysis using differential scanning calorimetry (DSC) to find the standard molar entropy of the co-crystals to solve for the Gibb’s free energy using the equation: ΔG = ΔH – TΔS.
Recommended Citation
Frederick, Aaron, "High Precision Combustion Calorimetry of Co-Crystals" (2015). Celebration of Undergraduate Research. 38.
https://digitalcommons.oberlin.edu/cour/2015/posters/38
Major
Chemistry
Project Mentor(s)
Manish Mehta, Chemistry and Biochemistry
Document Type
Poster
High Precision Combustion Calorimetry of Co-Crystals
Science Center, Bent Corridor
Co-crystals are solids of interest to many chemists, particularly pharmaceutical and materials scientists. The experiments I performed this summer provide thermodynamic data on co-crystals containing active pharmaceutical ingredients (APIs) including caffeine, theophylline, nicotinamide, and piracetam. These APIs were ground with a series of di-acids to make cocrystals, then analyzed using combustion calorimetry. Using a Parr 6200 calorimeter, I calculated the enthalpies of combustion and formation of these co-crystals. This enthalpy data is the first step in quantifying the spontaneous formation of co-crystals in this series of APIs. Future steps include analysis using differential scanning calorimetry (DSC) to find the standard molar entropy of the co-crystals to solve for the Gibb’s free energy using the equation: ΔG = ΔH – TΔS.
