Investigating complement system analogous immune response in Galleria mellonella
Location
CELA & Mary Church Terrell Library, First Floor
Document Type
Poster - Oberlin Community Only
Start Date
4-25-2025 12:00 PM
End Date
4-25-2025 2:00 PM
Abstract
Cervical radiculopathy is characterized by compression or irritation of a cervical nerve root at one or more vertebral levels in the setting of cervical foraminal stenosis and/or cervical disc herniation, with radicular pain being the most significant symptom. Through a retrospective cohort study, we sought to determine the impact of etiology on numerical pain score reduction following a cervical transforaminal epidural steroid injection (TF-ESI) for the management of cervical radicular pain. A chart review of 100 subjects who underwent TF-ESI to treat radicular pain showed the etiology to be cervical foraminal stenosis for 71 and cervical disc herniation for 29. A one-way analysis of variance (ANOVA) was conducted assessing the relationship between the etiology of cervical radiculopathy and self-reported numerical pain scores before and 1 month following TF-ESI. Stenosis subjects had a mean pre-procedure pain score of 6.56 (SD=1.59) and a mean pain score reduction post-procedure of 3.45 (SD=1.86). Herniation subjects had a mean pre-procedure pain score of 6.48 (SD=1.79) and a mean pain score reduction post-procedure of 2.69 (SD=1.85). The ANOVA analysis revealed a trend toward significance, but did not reach conventional statistical significance at the 0.05 threshold (F(1,98)=3.354, p=0.070). Given the near-significant p-value, future research exploring more patient-specific factors/pathologies will clarify variations in pain relief based on radiculopathy etiology to better understand influence on TF-ESI treatment response.
Keywords:
Galleria, Immunology
Recommended Citation
Wells, Braden, "Investigating complement system analogous immune response in Galleria mellonella" (2025). Research Symposium. 17.
https://digitalcommons.oberlin.edu/researchsymp/2025/posters/17
Major
Biology
Neuroscience
Project Mentor(s)
Gaybe Moore, Biology
2025
Investigating complement system analogous immune response in Galleria mellonella
CELA & Mary Church Terrell Library, First Floor
Cervical radiculopathy is characterized by compression or irritation of a cervical nerve root at one or more vertebral levels in the setting of cervical foraminal stenosis and/or cervical disc herniation, with radicular pain being the most significant symptom. Through a retrospective cohort study, we sought to determine the impact of etiology on numerical pain score reduction following a cervical transforaminal epidural steroid injection (TF-ESI) for the management of cervical radicular pain. A chart review of 100 subjects who underwent TF-ESI to treat radicular pain showed the etiology to be cervical foraminal stenosis for 71 and cervical disc herniation for 29. A one-way analysis of variance (ANOVA) was conducted assessing the relationship between the etiology of cervical radiculopathy and self-reported numerical pain scores before and 1 month following TF-ESI. Stenosis subjects had a mean pre-procedure pain score of 6.56 (SD=1.59) and a mean pain score reduction post-procedure of 3.45 (SD=1.86). Herniation subjects had a mean pre-procedure pain score of 6.48 (SD=1.79) and a mean pain score reduction post-procedure of 2.69 (SD=1.85). The ANOVA analysis revealed a trend toward significance, but did not reach conventional statistical significance at the 0.05 threshold (F(1,98)=3.354, p=0.070). Given the near-significant p-value, future research exploring more patient-specific factors/pathologies will clarify variations in pain relief based on radiculopathy etiology to better understand influence on TF-ESI treatment response.
