Chemokines and cytokines on the neuroimmunoaxis: Inner ear neurotrophic cytokines in development and disease. Prospects for repair?

Abstract

The earliest stages of neuronal and sensory cell development in vertebrate sensory organs depend on “inflammatory” immune system neurotrophic cytokines/chemokines. Although classical nerve growth factors, brain-derived neurotrophic factors and glial growth factors play critical roles at various stages, the earliest directive roles belong to immune system cytokines. In frogs, fishes, birds and mammals, macrophage migration inhibitory factor (MIF), monocyte chemoattractant protein 1 (MCP1) and RANTES, components of the otocyst-derived factor, are involved in sorting, morphogenesis, providing directional neuronal outgrowth cues as well as survival factors for both neurons and sensory cells. In this review we discuss their roles in the vertebrate inner ear.

Publisher

Elsevier

Publication Date

3-1-2018

Publication Title

Experimental Neurology

Department

Neuroscience

Document Type

Article

DOI

https://dx.doi.org/10.1016/j.expneurol.2017.10.009

Notes

Special Issue.

Keywords

Neurotrophic cytokines, Neuroimmunoaxis, Macrophage migration inhibitory factor (MIF), Monocyte chemoattractant protein 1 (MCP1), G-jun activation domain-binding protein-1 (Jab1), Inner ear, Hair cell development, Statoacoustic ganglion, Spiral ganglion, VIIIth nerve

Language

English

Format

text

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