Small molecule modulators of aggregation in synthetic melanin polymerizations
There are numerous potential applications for melanin-binding compounds, and new methods are of interest to identify melanin-binding agents. A portion of the polymerization to eumelanin, the black to brown pigment in humans, is thought to be supramolecular aggregation of nanoparticles derived from dihydroxyindoles. Starting with chloroquine, a known eumelanin-binding compound, the ability of small molecules to influence aggregation in synthetic eumelanin polymerizations was investigated. Twenty-eight compounds were tested, including pharmaceuticals, dyes, aromatics, and amines. Compounds that either accelerate or delay the appearance of macroscopic particles in synthetic eumelanin polymerizations were uncovered.
Belitsky, Jason M., Micah Z. Ellowitz, Diane Lye, and Alexander L. Kilbo. 2012. "Small molecule modulators of aggregation in synthetic melanin polymerizations." Bioorganic & Medicinal Chemistry Letters 22(17): 5503-5507.
Bioorganic & Medicinal Chemistry Letters
Chemistry and Biochemistry
This paper is dedicated to Professor J. Fraser Stoddart on the occasion of his 70th birthday.
Melanin, Eumelanin, Aggregation, Chloroquine, Congo red