Abstract
Inhibitors of melanin formation are sought after for a range of applications. Boronophenylalanine is known to inhibit melanogenesis via boronic acid-catechol interactions. A spectroscopic assay was developed to study the polymerization of L-dopa to synthetic melanin in the presence of para-substituted aryl boronic acids. The best inhibition was observed for aryl boronic acids with electron-withdrawing substituents. The IC50 values exhibit a correlation with the Hammett sigma(p) parameter (rho = 0.97, r(2) = 0.92).
Repository Citation
Belitsky, Jason M. 2010. "Aryl Boronic Acid Inhibition Of Synthetic Melanin Polymerization." Bioorganic & Medicinal Chemistry Letters 20(15): 4475-4478.
Publisher
Pergamon Press
Publication Date
8-1-2010
Publication Title
Bioorganic & Medicinal Chemistry Letters
Department
Chemistry and Biochemistry
Document Type
Article
DOI
https://dx.doi.org/10.1016/j.bmcl.2010.06.039
Keywords
Melanin, Boronic acid, Catechol, Hammett correlation
Document Version
post-print
Language
English
Format
text
