Event Title

Exploring the Dual Role of Gas as a Tumor Suppressor and Oncogene

Presenter Information

Sonam Patel, Oberlin College

Location

Science Center, Bent Corridor

Start Date

10-27-2017 6:00 PM

End Date

10-27-2017 6:40 PM

Research Program

National Institutes of Health

Poster Number

33

Abstract

Basal cell carcinoma is the most common form of skin cancer, with more than 4 million people diagnosed each year (Wong, 2003). Formation of basal cell carcinoma could occur through deletion of Gαs or repression of Protein kinase A (PKA) signaling (Iglesias-Bartolome, 2015). Gαs, a heterotrimeric signaling protein, can act both as a tumor suppressor and an oncogene (Turan, Bastepe, 2015). The tumor suppressor function of Gαs seems to be mediated by activation of PKA, while the tumor promoting function of Gαs is potentially mediated by Exchange protein activated by cAMP (EPAC). We hypothesize that Gαs possesses both properties because it is mediated by different downstream signaling pathways.

Major

Anthropology

Project Mentor(s)

Ramiro Iglesias-Bartolome and Maria Del Pilar Pedro, National Cancer Institute

This document is currently not available here.

Share

COinS
 
Oct 27th, 6:00 PM Oct 27th, 6:40 PM

Exploring the Dual Role of Gas as a Tumor Suppressor and Oncogene

Science Center, Bent Corridor

Basal cell carcinoma is the most common form of skin cancer, with more than 4 million people diagnosed each year (Wong, 2003). Formation of basal cell carcinoma could occur through deletion of Gαs or repression of Protein kinase A (PKA) signaling (Iglesias-Bartolome, 2015). Gαs, a heterotrimeric signaling protein, can act both as a tumor suppressor and an oncogene (Turan, Bastepe, 2015). The tumor suppressor function of Gαs seems to be mediated by activation of PKA, while the tumor promoting function of Gαs is potentially mediated by Exchange protein activated by cAMP (EPAC). We hypothesize that Gαs possesses both properties because it is mediated by different downstream signaling pathways.