Event Title
Monitoring Spontaneous Co-crystal Formation via In-Situ Solid-State NMR
Location
Science Center, Bent Corridor
Start Date
9-26-2014 12:00 PM
End Date
9-26-2014 1:20 PM
Poster Number
9
Abstract
Co-crystals are compounds composed of two or more chemically distinct species. A detailed understanding of the mechanism of organic co-crystal formation remains elusive. Techniques that interrogate a reacting system in situ are preferred, though experimentally challenging. We report an in situ study of the spontaneous formation of a co-crystal between a pharmaceutical mimic (caffeine) and a co-former (malonic acid) using 13C solid-state magic angle spinning NMR. We show that the formation of the co-crystal may be tracked in real time, and find no direct evidence for a short-lived amorphous solid intermediate.
Recommended Citation
Loewus, Sarel and Mandala, Venkata, "Monitoring Spontaneous Co-crystal Formation via In-Situ Solid-State NMR" (2014). Celebration of Undergraduate Research. 34.
https://digitalcommons.oberlin.edu/cour/2014/posters/34
Major
Biochemistry
Project Mentor(s)
Manish Mehta, Chemistry and Biochemistry
Document Type
Poster
Monitoring Spontaneous Co-crystal Formation via In-Situ Solid-State NMR
Science Center, Bent Corridor
Co-crystals are compounds composed of two or more chemically distinct species. A detailed understanding of the mechanism of organic co-crystal formation remains elusive. Techniques that interrogate a reacting system in situ are preferred, though experimentally challenging. We report an in situ study of the spontaneous formation of a co-crystal between a pharmaceutical mimic (caffeine) and a co-former (malonic acid) using 13C solid-state magic angle spinning NMR. We show that the formation of the co-crystal may be tracked in real time, and find no direct evidence for a short-lived amorphous solid intermediate.
