Event Title

Monitoring Spontaneous Co-crystal Formation via In-Situ Solid-State NMR

Location

Science Center, Bent Corridor

Start Date

9-26-2014 12:00 PM

End Date

9-26-2014 1:20 PM

Poster Number

9

Abstract

Co-crystals are compounds composed of two or more chemically distinct species. A detailed understanding of the mechanism of organic co-crystal formation remains elusive. Techniques that interrogate a reacting system in situ are preferred, though experimentally challenging. We report an in situ study of the spontaneous formation of a co-crystal between a pharmaceutical mimic (caffeine) and a co-former (malonic acid) using 13C solid-state magic angle spinning NMR. We show that the formation of the co-crystal may be tracked in real time, and find no direct evidence for a short-lived amorphous solid intermediate.

Project Mentor(s)

Manish Mehta, Chemistry and Biochemistry

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Sep 26th, 12:00 PM Sep 26th, 1:20 PM

Monitoring Spontaneous Co-crystal Formation via In-Situ Solid-State NMR

Science Center, Bent Corridor

Co-crystals are compounds composed of two or more chemically distinct species. A detailed understanding of the mechanism of organic co-crystal formation remains elusive. Techniques that interrogate a reacting system in situ are preferred, though experimentally challenging. We report an in situ study of the spontaneous formation of a co-crystal between a pharmaceutical mimic (caffeine) and a co-former (malonic acid) using 13C solid-state magic angle spinning NMR. We show that the formation of the co-crystal may be tracked in real time, and find no direct evidence for a short-lived amorphous solid intermediate.